…Factors produced by the above T cell subsets can be antigen-specific or antigen-nonspecific. Among these, the T cell growth factor produced by helper T cells is also called interleukin-2 (IL-2), and its primary structure has been determined in humans. It is a glycoprotein polymer with a molecular weight of 15,000. When resting T cells react with an antigen that corresponds to the antigen receptor on their surface, they enter the G1 phase of the cell cycle, where they synthesize a receptor that reacts with the growth factor. When this receptor appears on the cell surface and reacts with the growth factor, the T cell in the G1 phase enters the S phase, where it begins DNA synthesis. … *Some of the terminology that mentions "IL-2" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…また,上記T細胞サブセットが産生する因子には,それぞれ抗原特異的なものと,抗原非特異的なものとがある。このなかで,ヘルパーT細胞が産生するT細胞増殖因子は,インターロイキン‐2 interleukin‐2(IL‐2)とも呼ばれ,ヒトではその一次構造も決められており,分子量1万5000の糖タンパク質重合体である。 休止期T細胞がその表面の抗原受容体に対応する抗原と反応すると,細胞周期のG1期に入り,ここで増殖因子と反応する受容体を合成し,これが細胞表面に出て,増殖因子と反応すると,ここでG1期のT細胞は,DNA合成を始めるS期に入る。… ※「IL-2」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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