...It is an odorless white crystal that is insoluble in water but soluble in alcohol and acetone. It was predicted in the 19th century that the ovarian corpus luteum performs an endocrine function, but it was not until 1934 that progesterone, the main progesterone hormone, was extracted as crystals from the corpus luteum of pigs and other animals. This was done independently by A.F.J.Butenandt, K.H.Slotta, W.M.Allen, and M.Hartmann, who also succeeded in synthesizing it at roughly the same time. As described below, progesterone is secreted from the corpus luteum and placenta, but this hormone is an intermediate product of other steroid hormones and is also synthesized in the adrenal cortex and testes. *Some of the terminology explanations that mention "Slotta, KH" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…無臭の白色結晶で,水に溶けず,アルコール,アセトンに溶ける。卵巣の黄体が内分泌機能を行うことは19世紀から予測されていたが,黄体ホルモンの本体といえるプロゲステロンがブタなどの黄体から結晶として抽出されたのは1934年のことで,それはブテナントA.F.J.Butenandt,スロッタK.H.Slotta,アレンW.M.Allen,ハルトマンM.Hartmannらによってそれぞれ独立に行われ,ほぼ同じ時期に合成にも成功した。 プロゲステロンは,後述のように黄体,胎盤から分泌されるが,このホルモンは他のステロイドホルモンの中間産物で,副腎皮質や睾丸でも生合成される。… ※「Slotta,K.H.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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