...The serum concentrations of bile acids and cholesterol secreted into the bile also increase. In addition, as bile flow is impaired, the liver is damaged, and enzymes present in the biliary system, such as alkaline phosphatase, gamma-glutamyl transpeptidase (gamma-GTP), and leucine aminopeptidase (LAP), as well as enzymes in the liver cells, such as glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), are released into the blood, causing an increase in serum activity. Moreover, changes in the activity of these serum enzymes show characteristics depending on the site and nature of the damage, so these tests are useful for the differential diagnosis of jaundice. ... *Some of the terminology that mentions "glutamic oxaloacetic transaminase" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…胆汁中に分泌される胆汁酸およびコレステロールの血清中の濃度も上昇する。また胆汁流の障害に伴って,肝臓が障害されてアルカリホスファターゼ,γ‐グルタミルトランスペプチダーゼγ‐glutamyl transpeptidase(γ‐GTP),ロイシンアミノペプチダーゼ(LAP)など胆道系に存在している酵素と,肝細胞中のグルタミン酸オキサロ酢酸トランスアミナーゼglutamic oxaloacetic transaminase(GOT)やグルタミン酸ピルビン酸トランスアミナーゼglutamic pyruvic transaminase(GPT)などの酵素が血中に出てくるため,血清活性値が上昇する。しかも,これらの血清酵素活性値の変化には,障害の部位や性質に応じて特徴がみられるため,これらの検査は黄疸の鑑別診断に役立つ。… ※「glutamic oxaloacetic transaminase」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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