Aconitase

Japanese: アコニターゼ
Aconitase

EC 4.2.1.3. Also known as aconitate hydratase. An enzyme that catalyzes the reaction of adding water to cis -aconitate to produce citric acid or isocitrate. It is an enzyme involved in one step of the tricarboxylic acid cycle and is widely found in living organisms. In a system in which citric acid is continuously converted to isocitrate, cis -aconitate exists bound to the enzyme and does not become free. This enzyme has strict stereospecificity for the cis form. The ratio of each substance at equilibrium is citric acid: cis -aconitic acid: isocitric acid = 91:3:6. Mg2 + shifts the equilibrium towards citric acid. [CAS 9024-25-3]

Source: Morikita Publishing "Chemical Dictionary (2nd Edition)" Information about the Chemical Dictionary 2nd Edition

Japanese:

EC 4.2.1.3.アコニット酸ヒドラターゼともいう.cis-アコニット酸に水を付加し,クエン酸またはイソクエン酸を生成する反応を触媒する酵素.トリカルボン酸サイクルの1段階に関与する酵素で,生物界に広く存在する.クエン酸からイソクエン酸に連続的に変化する系では,cis-アコニット酸は酵素に結合した状態で存在し,遊離状態とならない.この酵素はシス形に対する厳密な立体特異性がある.平衡状態における各物質の存在比は,クエン酸:cis-アコニット酸:イソクエン酸 = 91:3:6である.Mg2+ は平衡をクエン酸側にずらす.[CAS 9024-25-3]

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