Lesch-Nyhan syndrome

…A healthy person's urine contains about 0.2 to 1.0 g (average 0.42 g) of uric acid per day, and the amount of uric acid in the blood is 2 to 4 mg/dl, not exceeding 5 mg/dl. However, in patients with gout or Lesch-Nyhan syndrome, large amounts of uric acid are found in the blood and urine due to abnormalities in purine metabolism. In patients with gout, the amount is 6 to 7 mg/dl, with a maximum of 20 mg/dl, and in patients with Lesch-Nyhan syndrome, the blood level is 10 mg/dl, and in urine it is 40 to 50 mg/kg of body weight per day. …

*Some of the terminology that mentions "Lesch-Nyhan syndrome" is listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

…健康なヒトの尿中には1日約0.2～1.0g(平均0.42g)の尿酸が含まれ，血中尿酸量は2～4mg/dlで，5mg/dlをこえない。ところが，痛風やレシュ=ナイハン症候群Lesch‐Nyhan syndromeの患者では，プリン代謝の異常のため，多量の尿酸が血中，尿中に見られる。痛風患者では6～7mg/dlで，最高20mg/dl，またレシュ=ナイハン症候群患者では血中濃度が10mg/dl，尿中では体重1kg当り40～50mg/日。…

※「Lesch-Nyhan syndrome」について言及している用語解説の一部を掲載しています。

出典｜株式会社平凡社世界大百科事典 第２版について | 情報