…For this reason, cAMP generally refers to the latter. It was discovered by EWSutherland and TWRall (1957) that cAMP plays an important role in the expression of the blood glucose-increasing action (glycogenolysis-promoting action) of epinephrine and glucagon, and was suddenly brought into the limelight. It is widely distributed in animal and plant tissues and bacterial cells, and is synthesized from ATP by the membrane-bound enzyme adenylate cyclase, which is activated by hormones and other stimuli. … *Some of the terminology that mentions "Sutherland, EW" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…このため単にcAMPと表記すれば普通は後者を指す。エピネフリンおよびグルカゴンの血糖値上昇作用(グリコーゲン分解促進作用)の発現にあたって重要な働きをする物質であることが,サザランドE.W.SutherlandとロールT.W.Rallによって見いだされ(1957),一躍脚光を浴びた。動植物組織や細菌細胞に広く分布し,ホルモンその他の刺激によって活性化される膜結合型の酵素,アデニル酸シクラーゼによって,ATPから合成される。… ※「Sutherland,E.W.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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