Melanosis coli

Japanese: 大腸黒皮症 - だいちょうこくひしょう（英語表記）melanosis coli

Also called melanosis coli. This condition is characterized by the deposition of melanin-like pigments mainly in the interstitium of the lamina propria mucosa, and sometimes in the muscularis mucosa and submucosa, causing the surface of the colonic mucosa to appear brown or blackish brown, with a leopard-striped or cobblestone-like pattern. The disease affects about 5 out of 100 people in Europe and the United States, but in Japan, it is said to affect 3 to 15 out of 100 people, and is common in people in their 40s to 60s, so it is not a rare condition. However, no special treatment is required. The cause is unknown, but it is often seen in people who tend to be constipated, and it is thought that the onset of this disease is related to the continuous use of anthracene laxatives.

Source: Heibonsha World Encyclopedia, 2nd Edition Information

Japanese:

大腸メラノーシスともいう。大腸の主として粘膜固有層の間質に，ときに粘膜筋板や粘膜下層に，メラニン様色素が沈着して大腸粘膜の表面が豹紋（ひようもん）状，あるいは石畳状に褐色または黒褐色を呈する状態をいう。発症は欧米で100人に5人前後であるが，日本では100人に3～15人といわれ40～60歳代に多く，まれな病変ではない。ただし，とくに治療の必要はない。原因は不明であるが，便秘傾向の人に多くみられ，アントラセン系下剤の連用が本症の発現に関連があると考えられている。

出典　株式会社平凡社世界大百科事典第２版について　情報

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