Aminopyrine

4-dimethylamino-2,3-dimethyl-1-phenyl-5-pyrazolone. _{C 13} H ₁₇ N ₃ O(231.30). 3-Methyl-1-phenyl-5-pyrazolone is synthesized from acetoacetate and phenylhydrazine, and this is then N -methylated, nitrosated, reduced, and methylated. Colorless or white crystals or crystalline powder. Odorless. Slightly bitter taste. Melting point 107-109 °C. Easily soluble in chloroform and ethanol, soluble in water and ether. Changes with light. It has reducing properties, and in the presence of an oxidizing agent, it shows a blue to purple color reaction. It is used as a pyrazolone synthetic antipyretic and analgesic. Its efficacy is about three times that of antipyrine. It may cause side effects such as nausea, tachycardia, hematoporphyrinuria, and agranulocytosis. [CAS 58-15-1]

Source: Morikita Publishing "Chemical Dictionary (2nd Edition)" Information about the Chemical Dictionary 2nd Edition

4-dimethylamino-2,3-dimethyl-1-phenyl-5-pyrazolone．C₁₃H₁₇N₃O(231.30)．アセト酢酸エステルとフェニルヒドラジンから3-メチル-1-フェニル-5-ピラゾロンを合成し，これをN-メチル化，ニトロソ化，還元，メチル化の工程を経て製造される．無色または白色の結晶，あるいは結晶性粉末．無臭．味はわずかに苦い．融点107～109 ℃．クロロホルム，エタノールに易溶，水，エーテルに可溶．光によって変化する．還元性があり，酸化剤の共存で，青～紫色の呈色反応を示す．ピラゾロン系合成解熱・鎮痛薬として用いられる．薬効はアンチピリンの約3倍．吐き気，頻脈，ヘマトポルフィリン尿症，無顆粒細胞症などの副作用を起こすことがある．[CAS 58-15-1]

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