An enzyme secreted from the bile duct that is involved in the liver's detoxification. It stands for gamma glutamyl transpeptidase. Processed waste products from the liver are excreted into the duodenum through the bile duct (a small bile duct that branches off inside the liver). However, if the bile duct is blocked by gallstones or cancer, enzymes such as γ-GTP and waste products flow back, causing the blood concentration to rise. γ-GTP is typically elevated in people who drink large amounts of alcohol. If other liver tests (GOT, GPT) are normal and this value is high, excessive drinking is likely the cause. The standard value varies slightly depending on the testing institution, but if it is 50 IU/l or less for men and 30 IU/l or less for women, it is normal. Other possible causes of this high value include alcohol consumption, as well as acute and chronic hepatitis, drug-induced liver damage, cirrhosis, liver cancer, and biliary diseases that cause jaundice. A study published in 1997 by Professor Furuno Junnori (Public Health) of Kyushu University's School of Medicine showed that the more coffee people drank, the lower their γ-GTP levels were. The average value for people who drank 30ml or more of alcohol every day and no coffee was 45 IU/l, while those who drank 1-2 cups of coffee had a value of about 40 IU/l, those who drank 3-4 cups had a value of about 35 IU/l, and those who drank 5 or more cups had a value of about 30 IU/l. As no results were found to show a decrease in γ-GTP with other drinks containing caffeine, such as green tea or black tea, it is believed that some component of coffee is involved. Source : Heibonsha Encyclopedia About MyPedia Information |
胆道から分泌され,肝臓の解毒作用に関与している酵素。ガンマグルタミルトランスペプチダーゼ(γ-glutamyl transpeptidase)の略。肝臓から処理済みの老廃物は,胆管(肝臓のなかにある枝別れした小さな胆道)を通して十二指腸に排泄されるが,胆道が胆石や癌(がん)などによって詰まると,γ-GTPなどの酵素や老廃物が逆流して,血中の濃度が上がる。 γ-GTPはアルコールを大量に飲んでいる人に特徴的に上昇する。ほかの肝臓検査(GOT,GPT)に異常がなく,この値だけが高い場合は,過度の飲酒が原因と考えられる。基準値は検査機関によって多少のばらつきがあるが,男性50 IU/l以下,女性30 IU/l以下であれば正常である。 この値が高い原因としては,飲酒のほか急性・慢性肝炎,薬物性肝障害,肝硬変,肝癌,黄疸が出るような胆道系の病気なども考えられる。 なお,1997年に発表された九州大学医学部の古野純典教授(公衆衛生学)らの研究によると,コーヒーをたくさん飲む人ほどγ-GTPの値が低くなるという結果が出た。毎日アルコールを30ml以上飲み,コーヒーをまったく飲まない人の平均値が45 IU/lだったのに対して,コーヒーを1〜2杯飲む人は約40 IU/l,3〜4杯では約35 IU/l,5杯以上は約30 IU/lだという。緑茶や紅茶など,カフェインを含むほかの飲み物では,γ-GTPが下がったという結果が出なかったことから,コーヒーのなんらかの成分が関与していると考えられる。
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