...It appears about 2 days before the rash and is therefore considered an important diagnostic finding. From [Immunoglobulin]...A general term for antibody proteins. Serum proteins are fractionated by electrophoresis into albumin and α-, β-, and γ-globulins, but most antibodies are found in the γ-globulin fraction, and since the majority of proteins in the γ-globulin fraction are antibodies, antibody proteins have long been called γ-globulins. In the 1960s, it was discovered that although there are several types of antibodies called classes and subclasses with partially different structures, all antibody proteins have a similar basic structure, and this came to be collectively called immunoglobulins. ... From [Immunotherapy]...In addition, the administration of monoclonal antibodies against more selective lymphocyte subsets is also considered as an immunosuppressive therapy, but it is not yet common. (2) As for immune replacement therapy, immunoglobulin therapy for agammaglobulinemia is the first to be mentioned. In addition, immunoglobulin therapy is also used to prevent general infections in patients with weakened immune systems. ... *Some of the terminology that mentions "γ-globulin" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…発疹の2日ほど前に現れるので,診断上重要な所見とされている。 【免疫グロブリン】より…抗体タンパク質の総称。血清のタンパク質は電気泳動によりアルブミンとα‐,β‐,γ‐グロブリンに分画されるが,抗体はほとんどがγ‐グロブリン画分に見いだされ,また,γ‐グロブリン画分のタンパク質の大部分は抗体であることから,抗体タンパク質は古くからγ‐グロブリンと呼ばれていた。1960年代に,抗体には部分的に構造の異なるクラスやサブクラスとよばれるいくつもの種類があるが,すべての抗体タンパク質は類似した基本構造をもつことが明らかとなり,これを免疫グロブリンと総称することになった。… 【免疫療法】より…そのほか,より選択的であるリンパ球のサブセットに対するモノクローナル抗体の投与も,免疫抑制療法の一つとして考えられているが,まだ一般的ではない。(2)免疫補充療法としては,無γ‐グロブリン血症に対する免疫グロブリン療法が第一にあげられよう。そのほか,免疫グロブリン療法は,免疫能の低下した患者の一般感染予防にも使用される。… ※「γ-グロブリン」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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