A metabolite of androgen. A male hormone isolated from adult male urine by AFJ Butenandt et al. (1934). Colorless crystals with a melting point of 185-185.5°C. It is sparingly soluble in water but readily soluble in most organic solvents. It is the standard substance for the international unit of male hormone activity, with 1 international unit being the increase in the comb area of a castrated rooster caused by 0.1 mg of it. Its biological activity is about one-tenth that of testosterone. It was synthesized from cholesterol by LS Ruzicka et al. (34) and its structure was determined. Source: Encyclopaedia Britannica Concise Encyclopedia About Encyclopaedia Britannica Concise Encyclopedia Information |
アンドロゲンの代謝物の1つ。 A.F.J.ブーテナントらにより成年男子尿から単離された (1934) 男性ホルモン。融点 185~185.5℃の無色結晶。水には難溶であるが,多くの有機溶媒には易溶。男性ホルモン作用の国際単位の基準物質で,その 0.1mgによる去勢雄鶏のとさか部面積の増加の程度に等しい作用を1国際単位としている。生物活性はテストステロンの約1/10程度。 L.S.ルジチカらによりコレステリンから合成され (34) ,構造が確定した。
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