Also called organizer or organizer. A germinal region that acts on adjacent germinal regions in animal embryo development and induces specific structures. H. Spemann and H. Mangold named the blastopore dorsal lip the organizer, because when the dorsal lip of the blastopore of a newt early sacculula was transplanted into another different germinal region, it differentiated into notochord and somites and at the same time differentiated the nervous system from the adjacent host tissue, and the two combined to form a secondary embryo. The function of determining the direction of differentiation of the adjacent tissues was called induction. The differentiation of organs in vertebrates is a series of induction chains that begins at the dorsal lip of the blastopore. The optic vesicle, which arises from a part of the initially induced neural plate, induces the epidermis to become a lens, and the lens further induces the cornea. Although many studies have been conducted to identify the causative inducer, a single causative substance has not been identified. organizer |
形成体または編成原ともいう。動物の胚発生において,隣接する胚域に働きかけ,特定の構造を誘導する働きをもつ胚域をいう。 H.シュペーマンおよび H.マンゴルトは,イモリ初期嚢胚の原口背唇部を他の異なった胚域に移植すると,それ自身脊索や体節に分化すると同時に接する宿主組織から神経系を分化し,両者が合して二次胚を形成することから,原口背唇部をオルガナイザーと命名。これに接する組織に分化の方向を決定する働きを誘導と呼んだ。脊椎動物の器官の分化は,原口背唇部に始る一連の誘導連鎖による。初めに誘導された神経板の一部から生じる眼胞は,表皮をレンズに,レンズはさらに角膜を誘導する。原因となる誘導物質の追究も数多くなされてきたが,単一の原因物質は得られていない。
オルガナイザー
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