…He discovered that adding polyuridylic acid (a polymer of U) to an in vitro protein synthesis system produced polyphenylalanine, and deduced that UUU was the codon for phenylalanine (Phe). Furthermore, HG Khorana's group organically synthesized various nucleic acids with a fixed base sequence and determined the amino acid sequence of the protein made from them, proving beyond doubt that the triplet bases in the genetic code table correspond precisely to each amino acid. All 64 types of codons had been completely elucidated by 1966. … *Some of the terminology references "Khorana, HG" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…彼は試験管内タンパク合成系にポリウリジル酸(Uの重合体)を加えると,ポリフェニルアラニンが生成することを発見し,UUUはフェニルアラニン(Phe)のコドンであると推論した。さらにコラナH.G.Khoranaのグループは,一定の塩基配列をもつさまざまな核酸を有機化学的に合成し,これらを用いて作られたタンパク質のアミノ酸配列を決定することにより,遺伝暗号表の三つ組塩基が各アミノ酸に正確に対応していることを疑問の余地なく証明した。64種のコドンのすべては,66年までに完全に解明された。… ※「Khorana,H.G.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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