...Tuberculosis prevention vaccine. In 1921, Calmette (1863-1933) and Camille Guérin (1872-1961) of the Pasteur Institute in France obtained a weak bacterium, Mycobacterium bovis, from 230 subcultures over 13 years on a potato medium containing 5% glycerin and ox bile. It did not cause progressive tuberculosis lesions when inoculated into animals, and it also provided strong immunity against tuberculosis infection. It was named BCG, an acronym for Bacille de Calmette et Guérin. Initially, they administered it orally to humans, but subsequent follow-up tests revealed that subcutaneous and intradermal injections were more effective in preventing tuberculosis. ... *Some of the terminology that mentions "Guérin, C." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…結核予防ワクチン。1921年,フランス・パスツール研究所のカルメットL.C.A.Calmette(1863‐1933)とゲランCamille Guérin(1872‐1961)がウシ型結核菌の5%グリセリン加ウシ胆汁ジャガイモ培地での13年間,230代にわたる継代培養から得た,動物に接種しても進行性結核病変を起こさず,かつ結核感染に対する強い免疫力が得られる弱毒菌で,Bacille de Calmette et Guérinの頭文字をとってBCGと命名された。当初,彼らはヒトに対して経口投与を行ったが,その後の追試により,皮下注射や皮内注射で結核予防効果がより確実となることが明らかにされた。… ※「Guérin,C.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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