...Soluble antigens can precipitate by forming complexes with antibodies (called precipitation reactions), or suspended matter such as bacteria and red blood cells can clump together (agglutination reactions). In antigen-antibody complexes, numerous antibody molecules are assembled by binding to the antigen, and such complexes stimulate cells because there are numerous receptors called Fc receptors on the surface of the cell membrane of the target cell, and the Fc portions of multiple antibody molecules in the complex bind to multiple receptors at multiple points, bridging the receptors. When immune complexes bind to phagocytes, the stimulation enhances the phagocytosis of the cells, and the complexes are quickly taken up into the cells. ... *Some of the terminology that mentions "Fc receptor" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…そのため,可溶性の抗原でも抗体と複合体をつくることによって沈殿し(沈降反応という),あるいは細菌,赤血球などの浮遊物が凝集する現象(凝集反応)がみられる。抗原・抗体複合体中では,数多くの抗体分子が抗原との結合によって集合しており,このような複合体が細胞を刺激するのは,標的となる細胞の細胞膜表面にFcレセプターとよばれる受容体が多数存在し,複合体中の複数の抗体分子のFc部分が複数の受容体と多点結合をして受容体を架橋するためである。 食細胞に免疫複合体が結合すると,その刺激によって細胞の食作用が亢進し,速やかに複合体は細胞内に摂取される。… ※「Fc レセプター」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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