…Novobiocin acts on bacterial DNA gyrase (an enzyme that reverses the double helix of bacterial DNA). Monensin, salinomycin, and other antibiotics form chelates with metal ions and are called ionophore antibiotics. Antimycin and oligomycin, which inhibit cellular energy production, are not selective and therefore highly toxic, but are important reagents in biochemistry. … *Some of the terminology explanations that mention "ionophore antibiotics" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…ノボビオシンは細菌のDNAジャイレースDNA gyrase(細菌DNAの二重らせんのよりをもどす酵素)に作用する。モネンシン,サリノマイシンなどは,金属イオンとキレートをつくり,イオノフォア抗生物質と呼ばれる。細胞のエネルギー産生を阻害するアンチマイシン,オリゴマイシンなどは,選択性がなく,したがって毒性も強いが,生化学的には重要な試薬となっている。… ※「イオノフォア抗生物質」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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