...Among these, drugs used to treat hypertension are called antihypertensive drugs. Antihypertensive drugs currently in use can be broadly categorized according to their mechanism of action into (1) drugs that act on blood vessels to dilate them, (2) drugs that dilate blood vessels by suppressing the activity of the sympathetic nervous system, which controls blood vessels and maintains vascular tone, (3) diuretics that promote the excretion of water and sodium to lower blood pressure, and (4) angiotensin antagonists. (1) Drugs that act on blood vessels Hydralazine, which acts directly on the smooth muscles of the vascular walls to relax them, has been used in treatment since the 1950s. ... *Some of the terminology that mentions "angiotensin antagonists" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…そのうち高血圧症の治療に使われるものを抗高血圧薬と呼ぶ。現在抗高血圧薬として使われているものを作用機序によって大別すると,(1)血管に作用してそれを拡張する薬物,(2)血管を支配して血管の緊張を維持している交感神経系の活性を抑えることにより血管を拡張させる薬物,(3)水とナトリウムの排出を促進して血圧を低下させる利尿降圧薬,(4)アンギオテンシン拮抗薬などがある。(1)血管に作用する薬物 血管壁の平滑筋に直接作用して弛緩させるものとしてヒドララジンが1950年代から治療に使われている。… ※「アンギオテンシン拮抗薬」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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