...(3) Cross-linking hypothesis: Cross-linking occurs between the side chains of polymers in the body over time, changing the shape of the molecules and altering their biological effects, or making them insoluble, and accumulating inside and outside the cells, impairing their functions. When cross-links form in DNA, RNA, or proteins, they are recognized as foreign bodies, which can cause autoimmune diseases, diabetes, cataracts, Alzheimer's fibrillary changes, and Parkinson's syndrome. The main component of connective tissue, which fills the gaps between cells and creates the microenvironment for cells, is collagen, a three-stranded fibrous protein, which performs mechanical functions such as support and reinforcement. ... *Some of the terminology that refers to "Alzheimer's fibrillary tangles" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…(3)架橋結合説 生体内の重合体の側鎖間に,時間の経過とともに架橋結合が生じて分子の形を変え,生物学的作用を変化させたり,不溶化とし,細胞の内外に蓄積して細胞の機能を損なうというものである。DNA,RNA,タンパク質に架橋が形成されると,異物として認識されるため自己免疫病の原因となり,糖尿病,白内障,アルツハイマー原繊維変化,パーキンソン症候群などのもとになる。細胞と細胞のすきまを埋めて,細胞の微小環境をつくっている結合組織の主要な構成成分は,3本鎖の繊維状タンパク質のコラーゲンで,支持,補強などの機械的機能を営んでいる。… ※「アルツハイマー原繊維変化」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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