It is a poisonous two-ring octapeptide (also called amatoxin or amanitatoxin) produced by certain mushrooms, including Amanita phalloides. There are α-, β-, and γ-amanitins, with α-amanitin being the most toxic. It causes cholera-like poisoning. It specifically inhibits RNA polymerase, especially RNA polymerase II. Source: Asakura Publishing Nutrition and Biochemistry Dictionary Information |
タマゴテングタケなど,ある種のキノコが生産する二つの環をもつオクタペプチド(アマトキシン,アマニタトキシンともいう)で有毒.α-,β-,γ-アマニチンがあるが,α-アマニチンが毒性が最も強い.コレラ様中毒を起こす.RNAポリメラーゼ,特にRNAポリメラーゼIIを特異的に阻害する.
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