…It is used as a symptomatic treatment to suppress the symptoms of various painful inflammatory diseases such as rheumatoid arthritis. It was developed in 1963 by American researchers TY Shen and CA Winter with the aim of improving the shortcomings of steroid anti-inflammatory drugs, which are extremely powerful but also have strong side effects and are used with caution. Not only was it the forerunner of the many non-steroidal anti-inflammatory drugs that have been developed since then, but it is also one of the most powerful and widely used of them all. Its essential mechanism of action is the same as that of aspirin, by suppressing the activity of cyclooxygenase, a basic enzyme in the biosynthesis of prostaglandins, known as local hormones. … *Some of the terminology that mentions "Winter, CA" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…関節リウマチなど,痛みを伴うさまざまの炎症性疾患の症状を抑えるための対症療法薬として使用される。きわめて強力ではあるが副作用もまた強いために警戒しながら使用されているステロイド抗炎症薬の欠点を改良することを狙って,アメリカのシェンT.Y.ShenとウィンターC.A.Winterが1963年につくりあげた薬物で,その後数多くつくられてきた非ステロイド抗炎症薬のさきがけをなしたというだけでなく,それらのなかでも最も強力な部類に属し広く使われている。本質的な作用メカニズムはアスピリンと同じで,局所ホルモンとして知られるプロスタグランジン類の生合成の基本的な酵素であるシクロオキシゲナーゼの働きを抑えるためである。… ※「Winter,C.A.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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