SRIF

Japanese: SRIF

...H-Thr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH ₂ GRF has a growth hormone secretion promoting effect. (3) Somatostatin It is also called GIF (short for growth hormone release inhibiting factor) or SRIF (short for somatotropin release inhibiting factor). In 1973, Guillemin et al. discovered a fraction from sheep hypothalamic tissue that inhibited the secretion of growth hormone, purified it, and determined the structure of somatostatin, which is made up of 14 amino acids.

From the hypothalamus

Growth Hormone

…One of the hormones secreted from the acidophilic cells of the anterior pituitary gland of vertebrates. Secretion is controlled by the hypothalamus and regulated by the inhibitory factor somatostatin (abbreviated as GIF, GIH, or SRIF) and the stimulatory factor (abbreviated as GRF or GRH). This hormone is a simple single-chain protein from bony fish to mammals, and has S-S bonds. …

From [Somatostatin]

...A hormone consisting of 14 amino acids, it was isolated and identified in 1973 by Brazeau P. Brazeau et al. from an extract of 500,000 sheep hypothalamus. Since it inhibits the secretion of growth hormone (also known as somatotropin), it is also called growth hormone inhibiting factor (abbreviated as GIF), growth hormone inhibiting hormone (GIH), or somatotropin release inhibiting factor (SRIF). Somatostatin inhibits not only growth hormone, but also the secretion of thyroid-stimulating hormone (TSH) from the pituitary gland, and also inhibits the secretion of hormones such as insulin, glucagon, and gastrin from the pancreas and digestive tract. ...

*Some of the terminology that mentions "SRIF" is listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…H－Thr－Ala－Asp－Ala－Ile－Phe－Thr－Asn－Ser－Tyr－Arg－Lys－Val－Leu－Gly－Gln－Leu－Ser－Ala－Arg－Lys－Leu－Leu－Gln－Asp－Ile－Met－Ser－Arg－Gln－Gln－Gly－Glu－Ser－Asn－Gln－Glu－Arg－Gly－Ala－Arg－Ala－Arg－Leu－NH₂GRFは成長ホルモン分泌促進作用をもつ。(3)ソマトスタチンsomatostatin　成長ホルモン分泌抑制因子GIF(growth hormone release inhibiting factorの略)あるいはSRIF(somatolropin release inhibiting factorの略)ともいう。1973年，ギルミンらは，ヒツジの視床下部組織から成長ホルモンの分泌を抑制する分画を発見し，純化を行って14個のアミノ酸からなるソマトスタチンの構造を決定した。…

【視床下部】より

【成長ホルモン】より

…脊椎動物の脳下垂体前葉の好酸性細胞から分泌されるホルモンの一つ。分泌は視床下部の支配を受け，抑制因子ソマトスタチンsomatostatin(GIF,GIHまたはSRIFと略記)と促進因子(GRFまたはGRHと略記)によって調節される。このホルモンは硬骨魚類から哺乳類に至るまで1本鎖の単純タンパク質で，S－S結合をもつ。…

【ソマトスタチン】より

…14個のアミノ酸からなるホルモンで，1973年ブラゾーP.Brazeauらによって，50万個のヒツジの視床下部の抽出物から分離，同定された。成長ホルモン(別名ソマトトロピン)の分泌を抑制することから，成長ホルモン放出抑制因子growth hormone inhibiting factor(GIFと略記)，growth hormone inhibiting hormone(GIH)，somatotropin release inhibiting factor(SRIF)とも呼ばれる。ソマトスタチンは，成長ホルモンだけでなく，脳下垂体からの甲状腺刺激ホルモン(TSH)の分泌を抑制し，さらにインシュリンやグルカゴン，ガストリンなど，膵臓や消化管からのホルモンの分泌を抑える作用ももつ。…

※「SRIF」について言及している用語解説の一部を掲載しています。

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