...Although this is a well-constructed theory, it certainly fits the reality of the immune system. NK Jerne (1911-94) further posits that all clones corresponding to non-self react with each other to form a kind of network and maintain the set (this is called the network theory). According to this theory, in order for an individual to have a set of clones that can react to any non-self it encounters, random combinations of antibody genes are created, and the cells expressing them react with each other to form a network, and the clones that do not enter the network are eliminated while the equilibrium state of the network is maintained. ... *Some of the terminology that mentions "Jerne, NK" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…うまくできた学説ではあるが,それは確かに免疫系の現実には合っている。イエルネN.K.Jerne(1911‐94)は,さらにすべての非自己に対応するクローンは,互いに反応し合いながら一種のネットワークをつくって,そのひとそろいを維持していると考える(これをネットワーク説という)。この考えによれば,個体がいかなる非自己と出会っても反応できるようなひとそろいのクローンを用意するために,ランダムな組合せの抗体遺伝子ができ,それを表現している細胞が互いに反応してネットワークをつくり,ネットワークに入らなかったクローンを除去すると同時に,ネットワークの平衡状態が維持されることになる。… ※「Jerne,N.K.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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