...However, a similar attempt had been made by J. Bordet et al. in France (1901), who also discovered the principle of complement fixation, so in France this reaction is often called the Bordet-Wassermann reaction. L. Detre of Budapest also independently published results using the same method about 10 days after Wasserman's report on monkeys, and before his report on humans. After that, it was thought that the antibodies in the patient's blood detected by this method were reagins, and not the pathogen itself, and from the 1940s onwards, lipid antigens made by adding lecithin and cholesterol to cardiolipin extracted from cow's hearts came to be used. ... *Some of the terminology that mentions "Detre, L." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…ただし,同様の試みはこれ以前にフランスのJ.ボルデらも行っており(1901),補体結合反応の原理をも見いだしていたので,フランスではこの反応をボルデ=ワッセルマン反応と呼ぶことが多い。またブダペストのデートルL.Detreも独立に同じ方法による結果を,ワッサーマンのサルについての報告の約10日後,ヒトについての報告の前に公表している。 その後,この方法で検出される患者血中の抗体はレアギンreaginで,病原体そのものではないと考えられるようになり,40年代以降になって,ウシの心臓から抽出されるカルジオライピンにレシチン,コレステロールを加えた脂質抗原が用いられるようになった。… ※「Detre,L.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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