…A neurological disease described by Hans G. Creutzfeldt (1885-1964) in 1920 and Alfons Jakob (1884-1931) in 1921. It affects both men and women from middle age onwards, and in the early stages, it shows personality changes and impaired memory and retention. Dementia then progresses, and the patient shows myoclonus (simultaneous, instantaneous muscle contractions of the limbs and trunk), pyramidal symptoms (motor paralysis, etc.), and extrapyramidal symptoms (abnormal muscle tone and involuntary movements, etc.). In the final stages, the patient becomes mutist and immobile, and dies within a few months to a year and a half. … *Some of the terminology references "Creutzfeldt, HG" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…1920年にクロイツフェルトHans G.Creutzfeldt(1885‐1964),翌21年にヤコブAlfons Jakob(1884‐1931)によって記載された神経疾患。中年以降に男女差なく発症,初期は性格変化や記憶・記銘力低下を示し,やがて痴呆が進行し,ミオクローヌスmyoclonus(四肢や体幹に同時的,瞬間的に起こる筋肉の収縮),錐体路症状(運動麻痺など)および錐体外路症状(筋緊張の異常と不随意運動など)を呈し,末期には無言無動状態となり,数ヵ月から1年半くらいの経過で死亡する。… ※「Creutzfeldt,H.G.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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