...Extreme heat (over 45°C), cold (under 15°C), excessive mechanical stimulation, irritating chemicals, etc. Surface pain seen during inflammation is caused by pain-inducing substances such as bradykinin and serotonin that are produced locally, and the peripheral nerve fibers involved in the pain caused by these pain-inducing substances are C fibers called polymodal nociceptive fibers. When inflammation is present, in addition to these pain-inducing substances, prostaglandin E 2 and prostaglandin I 2 are also produced locally. ... From 【Saliva】…Stimulation of the parasympathetic nervous system causes a large amount of saliva to be secreted, and at the same time, blood vessels in the salivary glands expand, increasing blood flow. This vasodilation is caused by the action of a polypeptide called bradykinin that is released locally. Saliva secretion occurs reflexively when taste stimuli are added. … *Some of the terminology that mentions "bradykinin" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…極端な熱(45℃以上),寒冷(15℃以下),過度の機械的刺激,刺激性のある化学物質などである。炎症のときにみられる表面痛は,局所に産生されるブラジキニンbradykinin,セロトニンなどの発痛物質によるもので,これらの発痛物質による痛みに関与する末梢神経繊維は,ポリモダル侵害受容繊維とよばれるC繊維である。炎症があると,これらの発痛物質のほか,プロスタグランジンE2とプロスタグランジンI2も局所に産生される。… 【唾液】より…副交感神経刺激によって多量の唾液が分泌され,同時に唾液腺の血管は拡張し血流量が増加する。この血管拡張は局所で遊離されたブラジキニンbradykininというポリペプチドの作用による。味覚刺激が加わると反射的に唾液分泌がおこる。… ※「bradykinin」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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