… By 1975, genetic engineering and DNA analysis techniques had made great advances, and it was revealed that src is a gene of about 1,600 nucleotides near the 3' end of the virus. Next, M. Bishop and his colleagues prepared a large amount of the src gene, labeled it with a radioisotope, and used it as a probe to detect the presence of DNA that complementarily binds to the probe. They confirmed (1976) that all vertebrate DNA contains DNA sequences that are highly similar to src. When the oncogenes of various RNA tumor viruses were analyzed, they were found to be different from each other. … *Some of the terminology that mentions "Bishop, M." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
… 75年までに,遺伝子操作技術とDNA解析技術が格段に進歩し,そのおかげでsrcはウイルスの3′末端付近の1600ヌクレオチドほどからなる遺伝子であることが明らかにされた。次いでビショップM.Bishopらは,src遺伝子を多量に調製してラジオアイソトープをつけ,これを探子probeとして探子に相補的に結合するDNAの存在を検出する方法により,すべての脊椎動物のDNAの中にsrcときわめて類似したDNA配列があることを確かめた(1976)。さまざまのRNA腫瘍ウイルスの癌遺伝子が解析されると,それらは互いに異なるものであることがわかった。… ※「Bishop,M.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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