Born April 6, 1928 in Chicago, Illinois. American geneticist and biophysicist. Proponent of the double helix theory of DNA (→ double helix). Graduated from the University of Chicago, he received his doctorate from Indiana University in 1950. He studied abroad at the University of Copenhagen, where he engaged in biochemistry research. In 1951, inspired by Oswald Avery's report (1944), he moved to the Cavendish Laboratory at Cambridge University to study the structure of DNA molecules. Watson applied X-ray analysis techniques to DNA, and in 1953, together with his collaborator Francis Crick, completed a model of the double helix structure of DNA molecules (→ Watson-Crick model). In the process, the correctness of the double helix theory was proven, and in 1962, he was awarded the Nobel Prize in Physiology or Medicine along with Crick and Maurice Wilkins. He was a professor at the California Institute of Technology from 1953 to 1955, and has been a professor at Harvard University since 1955. During this time, he contributed to deciphering the genetic code of DNA molecules and discovered messenger RNA. His book Molecular Biology of the Gene, first published in 1965, is widely used as an excellent textbook on molecular genetics and has been reprinted many times. His book The Double Helix (1968) is a retrospective of his research life around the time he invented the double helix model. In 1968, he became director of the Biometric Laboratory at Cold Spring Harbor Laboratory, the world's center of molecular biology research, and directed cancer research there until 2007. From 1988 to 1992, he served as leader of the Human Genome Project at the National Institutes of Health (NIH). Watson |
[生]1928.4.6. イリノイ,シカゴ アメリカ合衆国の遺伝学者,生物物理学者。デオキシリボ核酸 DNA二重螺旋説(→二重螺旋)の提唱者。シカゴ大学を卒業し,1950年インディアナ大学で学位取得。コペンハーゲン大学に留学し生化学研究に従事。1951年,オズワルド・エイブリーの報告(1944)にヒントを得て,DNA分子の構造を研究するため,ケンブリッジ大学のキャベンディッシュ研究所に移る。ワトソンは X線解析の技術を DNAに適用し,1953年共同研究者のフランシス・クリックとともに DNA分子の二重螺旋構造のモデル(→ワトソン=クリック模型)を完成。その過程で二重螺旋説の正しさが証明され,1962年にクリック,モーリス・ウィルキンズとともにノーベル生理学・医学賞を受賞した。1953~55年カリフォルニア工科大学教授を経て,1955年からハーバード大学教授。その間にも DNA分子の遺伝子暗号の解読に貢献し,メッセンジャーRNAを発見。1965年初版の『遺伝子の分子生物学』Molecular Biology of the Geneは,分子遺伝学の優れた教科書として広く用いられ,版を重ねた。著書『二重らせん』The Double Helix(1968)は,二重螺旋モデルを考案した頃の研究生活を回顧して書かれたものである。1968年分子生物学研究の世界的中心地であるコールド・スプリング・ハーバー研究所の計量生物学研究所所長となり,2007年まで癌研究の指揮をとった。1988~92年国立衛生研究所 NIHのヒトゲノム解析計画のリーダーを務めた。 ワトソン
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