A glycoprotein that plays a central role in blood coagulation reactions and is the first factor in blood coagulation. It is found in vertebrate plasma at 0.2-0.6% and is easily precipitated with salt or alcohol. Human fibrinogen has a molecular weight of 3.4 x 10 5 and is composed of six polypeptides (two each of the α, β, and γ chains). It contains hexose, glucosamine, and sialic acid as sugar components. The enzyme thrombin, which is produced when blood vessels rupture, acts on fibrinogen to produce four fibrinopeptides and fibrin monomers, which further polymerize to form fibrin clots and stop bleeding. [CAS 9001-32-5][See alternative terms] Fibrin Source: Morikita Publishing "Chemical Dictionary (2nd Edition)" Information about the Chemical Dictionary 2nd Edition |
血液凝固反応において中心的役割を果たす糖タンパク質で,血液凝固の第1因子である.脊椎動物の血漿中に0.2~0.6% 含まれ,塩あるいはアルコールにより容易に沈殿する.ヒトのフィブリノーゲンは分子量3.4×105,6本のポリペプチド(α,β,γ鎖各2本ずつ)で構成される.糖成分としてヘキソース,グルコサミン,およびシアル酸を含む.血管の破たんにより生成される酵素トロンビンがフィブリノーゲンに作用し,4本のフィブリノペプチドとフィブリンモノマーを生成し,フィブリンモノマーはさらに重合してフィブリン塊を形成して止血する.[CAS 9001-32-5][別用語参照]フィブリン 出典 森北出版「化学辞典(第2版)」化学辞典 第2版について 情報 |
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