Ibuprofen

2-(4-isobutylphenyl)propionic acid. _{C 13} H ₁₈ O ₂ (206.29). 2-(4-isobutylphenyl)propionic acid is synthesized by reacting ethyl (4-isobutylphenyl)acetate with diethyl carbonate to produce diethyl 2-(4-isobutylphenyl)malonate, which is then methylated and hydrolyzed (decarbonated). Colorless crystals. Melting point 75-77 °C. Easily soluble in many organic solvents, practically insoluble in water. A non-steroidal anti-inflammatory, analgesic, and antipyretic drug with 16-32 times the activity of aspirin. _{LD 50} 1255 mg/kg (mouse, oral). [CAS 15687-27-1]

Source: Morikita Publishing "Chemical Dictionary (2nd Edition)" Information about the Chemical Dictionary 2nd Edition

2-(4-isobutylphenyl)propionic acid．C₁₃H₁₈O₂(206.29)．(4-イソブチルフェニル)酢酸エチルに炭酸ジエチルを反応させて2-(4-イソブチルフェニル)マロン酸ジエチルとし，メチル化後，加水分解(脱炭酸)して合成する．無色の結晶．融点75～77 ℃．多くの有機溶媒に易溶，水にほとんど不溶．非ステロイド性の消炎，鎮痛，解熱薬で，アスピリンの16～32倍の作用を有する．LD₅₀ 1255 mg/kg(マウス，経口)．[CAS 15687-27-1]

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