…When the body comes into contact with a pathogenic antigen (through inhalation, oral ingestion, injection, etc.), the body begins to produce antibodies against it. Among these antibodies, the immunoglobulin Ig E antibody (also called reagin) has tissue adhesion properties and adheres to the surface of mast cells present in connective tissue. When the pathogenic antigen invades again, an antigen-antibody reaction occurs on the surface of the mast cells, resulting in the degranulation of the granules contained in the mast cells, releasing chemical messengers such as histamine, SRS-A (slow reactive substance of anaphylaxis), and ECF (eosinophile chemotactic factor) from the cells. … *Some of the terminology explanations that mention "reagin" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…病因となる抗原に生体が触れると(吸入,経口,注射などの経路で),生体はそれに対して抗体を産生するようになる。これらの抗体のうち,免疫グロブリンであるIg E抗体(レアギンreaginともいう)は組織固着性があり,結合組織中に存在するマスト細胞の表面に固着する。そこに病因となる抗原が再び侵入してくると抗原抗体反応がマスト細胞の表面で起こり,その結果,マスト細胞に含まれている顆粒が脱顆粒現象を起こし,顆粒の中に含まれているヒスタミン,SRS‐A(slow reactive substance of anaphylaxis),ECF(eosinophile chemotactic factor)などの化学伝達物質を細胞外に遊離する。… ※「reagin」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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