…Similarly to Woodward, he worked on the total synthesis of strychnine (alkaloid), tetracycline (antibiotic), chlorophyll a, vitamin B12 , etc. Otto Wallach (1847-1931), Richard Martin Willstätter (1872-1942), H. Fischer, P. Collar, RJ Kuhn, Adolf Friedrich Johann Butenandt (1903-95), and Robert Robinson (1886-1975) contributed to the development of the chemistry of terpenes, chlorophyll, vitamins, hormones, and alkaloids. The development of synthetic methods was inextricably linked to these developments. … From [Culture]…In 1926, TPS Strangeways and HB Fell of the Strangeways Laboratory in the UK developed a method of organ culture in which tissue fragments or organs are placed on a mixture of chicken plasma and embryo extract and exposed to air, preventing the proliferation of cells from migrating from the explant, and maintaining normal tissue structure without losing the overall shape. They then studied the development and differentiation of the primordium of chicken limbs. In 1929, Fell and R. Robinson developed the watch glass culture method. In 1952, E. Wolff and K. Haffen of France developed an organ culture method using nutrients suitable for organ growth and a semi-solid substrate, and used it to study sex differentiation, differentiation of embryonic organs, cancer, and other subjects. … *Some of the terminology that mentions "Robinson, R." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…ウッドワードは相前後して,ストリキニーネ(アルカロイド),テトラサイクリン(抗生物質),クロロフィルa,ビタミンB12などの全合成を手がけた。ワルラハOtto Wallach(1847‐1931),ウィルシュテッターRichard Martin Willstätter(1872‐1942),H.フィッシャー,P.カラー,R.J.クーン,ブテナントAdolf Friedrich Johann Butenandt(1903‐95),ロビンソンRobert Robinson(1886‐1975)らは,テルペン,クロロフィル,ビタミン,ホルモン,アルカロイドの化学の発展に貢献した。これらの発展と表裏一体の関係にあったのは合成法の発達である。… 【培養】より…イギリスのストレンジウェーズ研究所のストレンジウェーズT.P.S.StrangewaysとフェルH.B.Fellは,26年にニワトリ血漿と胚抽出物の混合凝固体の上に,組織片や器官を置いて空気にさらすことによって,増殖した細胞が外植体から遊走するのを抑え,全体の形を崩さずに正常な組織構造を保ったままで維持する器官培養の方法を完成し,ニワトリの肢の原基の発生と分化を研究した。さらに,フェルは29年に,ロビンソンR.Robinsonとともに時計皿培養法を完成した。52年になると,フランスのウォルフÉ.WolffとアッフェンK.Haffenとは,器官的成長に適した栄養分と半固体の基質からなる器官培養法を開発して,性分化現象,胚器官の分化,癌などの研究に供した。… ※「Robinson,R.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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