gnotobiote

Japanese: gnotobiote
gnotobiote

…Such animal groups are not necessarily free of microorganisms and parasites other than those specified. Other experimental animals that control microorganisms include germ-free animals and gnotobiotes. Germ-free animals are animals in which fetuses are removed by Caesarean section and hysterectomy, and are raised in a closed, aseptic manner so that they have no detectable microorganisms. Gnotobiotes are animals in which clearly identified microorganisms have been colonized in germ-free animals.

From [Experimental Animals]

...Because factors such as temperature and humidity also have a large impact, it is desirable to raise and manage animals in an air-conditioned room where light and other conditions are also controlled. Regarding microorganisms, which are important biological factors among environmental factors, germ-free animals with absolutely no other living organisms in their bodies, SPF animals that have been proven to be free of specific microorganisms, and gnotobiotes that only have known organisms in their bodies have been developed and are used as microbial-controlled experimental animals. There are three uses for experimental animals: research, testing, and production. ...

*Some of the terminology explanations that mention "gnotobiote" are listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…このような動物群では指定以外の微生物・寄生虫は必ずしもフリーではない。また微生物を制御している実験動物としてはこのほか,無菌動物,ノトバイオートgnotobioteなどがある。無菌動物は帝王切開・子宮切断により胎児をとり出し,封鎖方式で無菌処置で哺育させ,検出可能な微生物がないものであり,ノトバイオートは無菌動物に明らかに同定された微生物を定着させている動物を指す。…

【実験動物】より

…温度,湿度などの因子も影響が大きいから,空調の設備があって,光などの条件もコントロールされた飼育室で飼養管理されることが望ましい。環境要因中,生物因子として重要な微生物については,体内にまったく他生物のいない無菌動物,特定の微生物のいないことが証明されているSPF動物,体内に既知の生物しかいないノトバイオートgnotobioteなどが開発され,微生物統御実験動物として使われている。 実験動物の用途には研究用,検定用,製造用の三つがある。…

※「gnotobiote」について言及している用語解説の一部を掲載しています。

出典|株式会社平凡社世界大百科事典 第2版について | 情報

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