…The M4 type has a higher affinity for pyruvate than the H4 type, and the M4 type enzyme in skeletal muscle rapidly converts pyruvate to lactate. The isozymes are very similar, but are controlled by different genes, and it is thought that these genes were originally one gene, but gradually changed after multiple genes were duplicated during the course of evolution. [Mitsuhiro Yanagida]. … *Some terminology explanations that mention "gene duplication" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…M4型はH4型よりピルビン酸に対する親和性が高く,骨格筋中のM4型酵素はピルビン酸を乳酸に迅速に変える。アイソザイムは,非常によく似ているが,異なった遺伝子によって支配されていて,これらの遺伝子はもともと一つであったものが進化の過程で遺伝子重複gene duplicationにより複数化した後徐々に変化したものであろうと考えられている。【柳田 充弘】。… ※「gene duplication」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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