epitope

Japanese: epitope
epitope

... The functions of an antigen are not present in the entire antigen molecule, but are closely related to the chemical and three-dimensional structure of a specific portion of the antigen molecule. Such a portion is called a determinant or epitope, and in most cases, it has a molecular weight of 500 to 1000 and is about 4 x 2 x 1 nm in size, and consists of 5 to 8 amino acids for protein antigens and 5 to 6 monosaccharides for polysaccharide antigens.
[Antigen specificity and its basis]
Antibodies produced by the body in response to a particular antigen (or present in small amounts in normal animals) or sensitized lymphocytes react only with determinants specific to that antigen.

*Some of the terminology explanations that mention "epitope" are listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

… 抗原のこのような機能は抗原分子全体にあるのではなく,その限定された部位がもつ化学的・立体的構造との関連が深い。このような部分を決定群(基)またはエピトープepitopeと呼び,多くの場合,分子量500~1000で4×2×1nmくらいの大きさをもち,タンパク質抗原ではアミノ酸5~8個,多糖体抗原なら単糖5~6個くらいの大きさからなる。
[抗原特異性とその基盤]
 特定の抗原の免疫で生体がつくった(または正常動物が少量もつ)抗体または感作リンパ球は,その抗原に特有な決定群とのみ反応する。…

※「epitope」について言及している用語解説の一部を掲載しています。

出典|株式会社平凡社世界大百科事典 第2版について | 情報

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