Connect

Japanese: connectin
Connect

…Animal cells are covered with collagen, fibronectin, lamin, and other proteins that are synthesized and secreted by the cells, and these proteins affect the morphology and function of the cells by interacting with the cell membrane. Lamin can bind to actin filaments on the cell surface via connectin, and fibronectin can bind to actin filaments via binding proteins that penetrate the cell membrane, resulting in a structure that can link with the cytoskeleton. It is known that when cells become cancerous, the mesh structure of fibronectin that develops to wrap around the outside of the cell is significantly reduced at the same time as the cell morphology changes. This phenomenon is related to changes in the distribution of actin filaments, such as actin filaments detaching from the cell membrane and stress fibers becoming invisible. …

*Some of the terminology that mentions "connectin" is listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…動物細胞は,細胞が合成し分泌したタンパク質であるコラーゲンcollagen,フィブロネクチンfibronectin,ラミンlaminなどによって覆われ,また,これらのタンパク質は細胞膜と相互作用することによって細胞の形態や機能に影響を与えている。ラミンはコネクチンconnectinを介して細胞表層のアクチン繊維と結合でき,フィブロネクチンは細胞膜を貫く結合タンパク質を介してアクチン繊維と結合でき,結果として,細胞骨格と連動しうる構造になっている。癌化に際して,細胞形態の変化と同時に,細胞の外側を包み込む形で発達しているフィブロネクチンの網目構造が著しく減少することが知られているが,この現象は細胞膜からアクチン繊維が離れ,ストレスファイバーが見えなくなるなど,アクチン繊維の分布の変化と関係がある。…

※「connectin」について言及している用語解説の一部を掲載しています。

出典|株式会社平凡社世界大百科事典 第2版について | 情報

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