…In 1923, Arthur F. Coca proposed the term to encompass a group of allergic diseases with strong hereditary tendencies, including hay fever (hay fever) and bronchial asthma. In 1925, Coca himself demonstrated that an antibody-like substance, which could be confirmed by skin reactions, was present at a high rate in the serum of patients with atopic dermatitis, and Coca named this substance atopic reagin. In 1966, Kosei Ishizaka and others demonstrated that atopic reagin is an antibody belonging to immunoglobulin (IgE) with unique biological activity. … *Some of the terminology explanations that mention "atopic reagin" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…1923年コカArthur F.Cocaが,枯草熱(花粉症),気管支喘息(ぜんそく)を中心とする遺伝傾向が強い一群のアレルギー性疾患を包括する疾患概念として提唱したものである。25年にはコカ自身によって,アトピー罹患患者の血清中に,皮膚反応によって証明される抗体様物質が高率に存在することが明らかにされ,コカはこの物質をアトピー性レアギンatopic reaginと名づけた。このアトピー性レアギンの本態は,66年石坂公成らにより,特異な生物活性をもった免疫グロブリン(IgE)に属する抗体であることが証明された。… ※「atopic reagin」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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