SI (medicine) - SI

Japanese: SI(薬) - えすあい
SI (medicine) - SI

...It is a chemotherapy agent against bacteria and was the mainstay of chemotherapy until the development of antibiotics.
[Development History]
In 1935, G. Domagk of Germany discovered that sulfanilamide chrysoidine (brand name Prontosil), developed in 1932, was effective against streptococcal sepsis in mice. In the same year, J. Trefouël, a bacteriologist at the Pasteur Institute in France, and his colleagues revealed that the active ingredient in Prontosil was sulfamine, which is produced when Prontosil is broken down in the body.

*Some of the terminology explanations that mention "SI (medicine)" are listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…細菌に対する化学療法剤で,抗生物質が開発されるまでは化学療法の中心的存在であった。
[開発の歴史]
 1935年,ドイツのG.ドーマクは32年に開発されたスルファニルアミドクリソイジン(商品名,プロントジルProntosil)が連鎖球菌によるマウスの敗血症に有効であることを発見した。同年,フランスのパスツール研究所の細菌学者であったトレフエルJ.Trefouëlらは,プロントジルの有効成分はプロントジルが体内で分解されてできるスルファミンであることを明らかにした。…

※「SI(薬)」について言及している用語解説の一部を掲載しています。

出典|株式会社平凡社世界大百科事典 第2版について | 情報

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