...(2) Drugs that inhibit enhanced fibrinolysis When the system that produces the enzyme plasmin, which dissolves blood clots, from plasminogen in the blood (fibrinolysis system) is in an enhanced state, fibrin, fibrinogen, and other clotting factors are destroyed, causing a tendency to bleed. For example, antiplasmin drugs such as epsilon-aminocaproic acid and tranexamic acid are effective in treating such bleeding that can occur after pneumonia, colitis, or surgery on the prostate, bladder, or ureter. (3) Vascular strengthening drugs Ascorbic acid, adrenochrome derivatives, rutin, hesperidin, and other flavonoids suppress the permeability of capillaries, improve their fragility, and exert a hemostatic effect. ... *Some of the terminology explanations that mention "epsilon-aminocaproic acid" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…(2)亢進した繊維素溶解を阻止する薬物 凝血を溶解する酵素プラスミンを血液中のプラスミノーゲンから生成する系(繊維素溶解系)が亢進した状態では,フィブリン,フィブリノーゲンその他の凝血因子が破壊されて出血傾向があらわれる。たとえば肺炎,結腸炎,あるいは前立腺,膀胱,尿管などの手術後にみられることのあるそのような出血にはイプシロン‐アミノカプロン酸,トラネキサム酸などの抗プラスミン薬が有効となる。(3)血管強化薬 アスコルビン酸,アドレノクロム誘導体,ルチン,ヘスペリジンその他のフラボノイドが,毛細血管の透過性を抑え脆弱(ぜいじやく)性を改善して止血効果を発揮する。… ※「イプシロン‐アミノカプロン酸」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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