...This compound was not put to practical use due to its high toxicity, but a huge number of antihistamines were developed and used after that, and a considerable number are still in use today. H2 blockers were discovered in 1972 by Black and others at the French pharmaceutical company Smith Kline & French, who found that brimamide and then metiamide antagonized the effects of histamine that were not antagonized by conventional antihistamines from among about 700 compounds. This was the beginning of the concept of H1 and H2 action. These were not put to practical use, but cimetidine, which was developed next, was used as a treatment for stomach ulcers because it suppresses histamine-induced gastric acid secretion. ... *Some of the terminology that mentions "metiamide" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…この化合物は毒性の強さから実用にはならなかったが,その後膨大な数の抗ヒスタミン薬が開発・使用され,現在でも相当数のものが使用されている。H2遮断薬は,フランスの製薬会社スミス・クライン・アンド・フレンチ社のブラックBlackらが約700種の化合物の中からブリママイドbrimamide,次いでメチアマイドmetiamideという化合物が従来の抗ヒスタミン薬で拮抗されないヒスタミンの作用に拮抗することを見いだし(1972),これがH1作用,H2作用という概念を生む端緒となった。これらは実用化には至らなかったが,次いで開発されたシメチジンは,ヒスタミンの胃酸分泌を抑制することから,胃潰瘍治療薬として実用化されるに至った。… ※「metiamide」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
<<: Methymna (English spelling)
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