pyrazinamide

...If resistance develops to any of the antituberculosis drugs listed above or if they cannot be used due to side effects, other drugs will be used instead. In terms of effectiveness and side effects, kanamycin (abbreviated as KM) and ethionamide (abbreviated as TH) are easy to use. Pyrazinamide (abbreviated as PZA) is highly regarded in Europe and the United States and is used for the first two months of short-term chemotherapy, but it is not used much in Japan due to its strong side effects. The main side effects are hearing loss caused by mycin-based drugs, balance disorders caused by streptomycin sulfate, liver damage caused by TH, PZA, and RFP, vision loss caused by EB, mental disorders caused by cycloserine (abbreviated as CS) and TH, peripheral neuritis caused by INH and EB, gastrointestinal disorders caused by TH and PAS, and allergic reactions to various drugs. ...

*Some of the terminology explanations that mention "pyrazinamide" are listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

…上記の処方中の抗結核薬のいずれかに耐性が生じたり，副作用で使えないときには，その薬に代えて他の薬を用いることになるが，効果と副作用からみて用いやすいのはカナマイシンkanamycin(KMと略記)，エチオナミドethionamide(THと略記)などである。ピラジナミドpyrazinamide(PZAと略記)は欧米では高く評価され，短期化学療法の当初2ヵ月くらい用いられているが，副作用が強く日本では多くは使われていない。　副作用のおもなものは，マイシン系薬剤による聴力障害，硫酸ストレプトマイシンによる平衡障害，TH･PZA･RFPの肝臓障害，EBの視力障害，サイクロセリンcycloserine(CSと略記)･THの精神障害，INH･EBの末梢神経炎，TH･パスによる胃腸障害，各種薬剤に対するアレルギー反応などである。…

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出典｜株式会社平凡社世界大百科事典 第２版について | 情報