…But in 1915, Japanese scientists Katsusaburo Yamagiwa and Koichi Ichikawa became the first in the world to artificially create cancer through stimulation, after years of painstaking experimentation in which they smeared tar on the ears of rabbits. Encouraged by this success, a group of British chemists energetically searched for carcinogens, and in 1928, E. Kennaway (1881-1958) revealed the carcinogenicity of the synthetic hydrocarbon 1,2,5,6-dibenzanthracene, and in 1933, J. Cook identified the carcinogen in tar as 3,4-benzopyrene. Meanwhile, in 1932, Takaoki Sasaki and Tomizo Yoshida succeeded in inducing liver cancer in rats by feeding them o -aminoazotoluene, a type of azo dye, mixed with their feed. … *Some of the terminology that mentions "Kennaway, E." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…しかるに1915年,日本の山極勝三郎と市川厚一は,ウサギの耳に年余にわたりタールを塗りつづけるという忍耐強い実験の結果,世界にさきがけて人工的に〈刺激〉により癌をつくり出すことに成功したのである。この成功に力を得て,イギリスの化学者グループが癌原物質の探索を精力的に行い,28年,ケナウェーE.Kennaway(1881‐1958)は合成炭化水素1,2,5,6‐ジベンズアントラセンの癌原性を明らかにし,33年にはクックJ.Cookがタール中の癌原物質が3,4‐ベンツピレンであることをつきとめた。他方,佐々木隆興と吉田富三は1932年,アゾ色素の一種であるo‐アミノアゾトルエンを飼料に混ぜてラットに与え,肝臓癌を発生させることに成功した。… ※「Kennaway,E.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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