Drug hypersensitivity

Japanese: 薬物過敏症 - やくぶつかびんしょう

This refers to an abnormal hypersensitivity reaction that is undesirable to the living body, induced by the administration of a normal dose or less of a drug. In many cases, it occurs due to an underlying abnormality in the patient's constitution. At the end of the 19th century, E. von Behring observed that when he repeatedly injected animals with bacterial toxins, sometimes a very small amount of the toxin, less than the lethal dose, caused severe shock symptoms. He believed that this was because the animals had become hypersensitive to the toxin, and called this state "hypersensitivity."

Source: Heibonsha World Encyclopedia, 2nd Edition Information

Japanese:

常用量もしくはそれ以下の薬物の投与で誘発される，生体にとって望ましくない異常な過敏反応をいう。被投与者の体質上の異常が根底にあって発生する場合が多い。19世紀末にE.vonベーリングが，動物に細菌の毒素をくりかえし注射していくと，ときに致死量以下のごく少量の毒素の注射で激しいショック症状をおこすことを観察し，それは動物がその毒素に対して過敏になっているためと考え，その状態をhypersensitivity(過敏状態。

出典　株式会社平凡社世界大百科事典第２版について　情報

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