Strychnine

Also called strychnine. C ₂₁ H ₂₂ N ₂ O ₂ (334.41). An indole alkaloid found in the seeds of Strychnos nux-vomica (Buddhistaceae). It is obtained together with its dimethoxy derivative brucine. Melting point 268°C. -139° (chloroform). 1.36. p K _a1 8.0, p K _a2 2.3 (20°C). UVλ _max 254, 278, 288 nm (log ε 4.10, 3.63, 3.53 ethanol). Slightly soluble in water, ether, and cold ethanol. A highly poisonous substance that stimulates and excites the central nervous system. It can also cause characteristic rigid convulsions and lead to death. The lethal dose for humans is 30-100 mg. It is used as a nerve stimulant to aid in recovery from illness and to treat digestive dysfunction. [CAS 57-24-9]

Source: Morikita Publishing "Chemical Dictionary (2nd Edition)" Information about the Chemical Dictionary 2nd Edition

ストリキニンともいう．C₂₁H₂₂N₂O₂(334.41)．フジウツギ科Strychnos nux-vomicaの種子(まちんし，馬銭子)に含まれるインドールアルカロイドの一種．ジメトキシ誘導体のブルシンとともに得られる．融点268 ℃．－139°(クロロホルム)．1.36．pK_a1 8.0，pK_a2 2.3(20 ℃)．UVλ_max 254，278，288 nm(log ε 4.10，3.63，3.53エタノール)．水，エーテル，冷エタノールに難溶．猛毒で中枢神経を刺激し興奮させる．さらには特有の硬直性けいれんを起こし，死に至らせる．ヒトに対する致死量30～100 mg．神経興奮薬として病後の回復に，あるいは消化器機能不全の治療に用いる．[CAS 57-24-9]

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