Guanethidine - Guanethidine

Japanese: グアネチジン - ぐあねちじん

...The alkaloids of the Indian jasmine, represented by reserpine, contribute to lowering blood pressure by both having a sedative effect on the central nervous system and by depleting the excitatory transmitter noradrenaline from the sympathetic nerve endings in the periphery. Guanethidine blocks the connection between sympathetic nerve excitation and the release of noradrenaline from the nerve endings, preventing sympathetic nerve excitation from being transmitted to the blood vessels. It is also said that continued use gradually produces a noradrenaline depletion effect similar to that of reserpine. ...

From [Autonomic Nervous System Drugs]

…Unlike alpha-blockers and beta-blockers, they cannot block the action of sympathomimetics that bind directly to receptors. Drugs such as guanethidine, betanidine, and reserpine belong to this category. They dilate blood vessels and lower blood pressure. …

*Some of the terminology that mentions "guanethidine" is listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…レセルピンを代表とするインドジャボクのアルカロイド類は，中枢での静穏作用と，末梢での交感神経終末から興奮伝達物質のノルアドレナリンを枯渇させる作用とがともに血圧降下に寄与している。グアネチジンは，交感神経興奮と神経終末からのノルアドレナリン遊離との連関を遮断して，血管に交感神経の興奮が伝わらなくする。また，連用によってしだいにレセルピンのようなノルアドレナリン枯渇作用が現れるといわれている。…