Pseudomembranous colitis

...This is because the amount of antibiotics used is greater than that used in outpatient settings, many patients have weakened resistance to infection, and there are many opportunities for resistant bacteria to invade. To give a few specific examples, taking tetracycline for a long period of time can cause abnormal proliferation of Candida in the intestines, and continued use of antibiotics can cause the proliferation of Clostridium difficile , a type of anaerobic bacteria, in the intestines, which can cause pseudomembranous colitis due to its toxins, and during antibiotic therapy for sepsis, the causative bacteria can change from Staphylococcus aureus to Pseudomonas aeruginosa. Compared to the time when the terms bacterial replacement phenomenon and bacterial replacement disease were coined, treatment has become more advanced and complicated in recent years, and infectious diseases have changed dramatically, especially with the widespread use of immunosuppressants. ...

*Some of the terminology that mentions "pseudomembranous colitis" is listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

…抗生物質の使用量が外来通院時に比べて多いほか，感染抵抗力が低下した患者が多く，かつ耐性菌侵入の機会が多いためである。二，三の具体例をあげると，テトラサイクリンを長期内服すると腸管内のカンジダが異常に増殖し，また抗生物質連用時に腸管内で嫌気性菌の一種であるクロストリジウム･ディフィシルClostridium difisileが増殖し，その毒素によって偽膜性大腸炎を起こしたり，敗血症の抗生物質療法時に原因菌がブドウ球菌から緑膿菌に交代するといったことなどである。　菌交代現象，菌交代症という言葉が生まれた時代に比べると，昨今では治療内容が高度化，複雑化し，とくに免疫抑制剤の汎用に伴って感染症は著しく変貌した。…

※「偽膜性大腸炎」について言及している用語解説の一部を掲載しています。

出典｜株式会社平凡社世界大百科事典 第２版について | 情報