...The most well-known are Langhans giant cells in tuberculosis lesions and Sternberg giant cells found in lymphogranuloma and tissues of Hodgkin's disease patients. Later, it was confirmed that many viruses, such as influenza virus, measles virus, cowpox virus, and mouse Sendai virus (also called HVJ virus, an abbreviation for hemagglutinin virus of Japan), can cause cell fusion in vivo and in test tubes, leading to the development of artificial cell fusion methods. To artificially cause cell fusion in a test tube, viruses inactivated by ultraviolet light or treatment with polyethylene glycol dissolved in culture medium at a concentration of 20 to 30% are used. ... *Some of the terminology that refers to "HVJ virus" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…結核病巣中のラングハンス巨細胞,リンパ肉芽腫やホジキン病患者の組織に見いだされるシュテルンベルグ巨細胞が有名である。その後,インフルエンザウイルス,はしかや牛痘ウイルス,マウスのセンダイウイルス(HVJウイルスとも呼ばれる,hemagglutinin virus of Japanの略)など,多くのウイルスが生体内および試験管内で細胞融合を起こすことが確かめられ,人為的な細胞融合法の開発に結びついた。人為的に試験管内で細胞融合を起こすには,紫外線で不活性化したウイルスや,20~30%の濃度で培養液中に溶解したポリエチレングリコールによる処理が用いられる。… ※「HVJ ウイルス」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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