...This enzyme inhibitory effect is thought to be related to the antidepressant effect, and by around 1964 many monoamine oxidase inhibitors had appeared as antidepressants, but they fell out of use because they were only effective for psychogenic depression and caused liver damage. On the other hand, Kuhn discovered that imipramine (trade names: Imidol, Tofranil), which was developed as a sedative, had the power to improve depression, and so-called tricyclic antidepressants such as its derivatives desmethylimipramine (trade names: Pertofuran), amitriptyline (trade names: Adepress, Lantron, Tryptanol), nortriptyline (trade name: Noritren), protriptyline, and doxepin appeared one after another. Monoamine oxidase inhibitors increase the activity of serotonin and catecholamines, which are neurostimulants in the brain. ... *Some of the terminology that mentions "imidol" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…この酵素抑制作用が抗鬱作用と関係があると考えられ,64年くらいまでに多くのモノアミン酸化酵素抑制薬が抗鬱薬として登場したが,心因性鬱病にしか効かないことと肝障害を起こすことから利用されなくなった。他方,鎮静薬として作られたイミプラミン(商品名イミドール,トフラニール)が鬱状態を改善する力をもっていることがクーンによって見いだされ,以後その誘導体であるデスメチルイミプラミン(商品名ペルトフラン),アミトリプチリン(商品名アデプレス,ラントロン,トリプタノール),ノルトリプチリン(商品名ノリトレン),プロトリプチリン,ドキセピンなどのいわゆる三環系抗鬱薬が続々と登場した。モノアミン酸化酵素抑制薬は脳内の神経刺激伝達物質であるセロトニンやカテコールアミンなどの活性を高める。… ※「イミドール」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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