…(1) Phase 1 reaction The binding of an antigen and an antibody does not occur in the entirety of both molecules, but through the binding of structural parts on both molecules that fit together perfectly, with a relationship likened to that of a key and a lock. The parts involved in such binding are called determinants or epitopes in antigens, and antigen-binding sites or allotopes in antibodies. Furthermore, the physical forces involved in the binding of determinants and antigen-binding sites are thought to include Coulomb's electrostatic forces, van der Waals forces, hydrogen bonds, hydrophobic repulsion, etc., which are derived from the mutual structures. … *Some of the terminology that mentions "allotope" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…(1)第1相の反応 抗原と抗体の結合は,両分子の全体で起こるのではなく,両者の上にあって〈鍵と鍵穴〉にたとえられる関係をもった相互にぴったり合う構造部分の結合によって起こる。そのような結合に関与する部位を,抗原では決定群,エピトープ,抗体では抗原結合部位,アロトープなどと呼ぶ。さらに,決定群と抗原結合部位の結合に関与する物理的力には,相互の構造に由来するクーロンの静電力,ファン・デル・ワールスの力,水素結合,疎水性反発力等の関与が想定されている。… ※「アロトープ」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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