Pernicious anemia

Japanese: 悪性貧血 - あくせいひんけつ(英語表記)pernicious anemia
Pernicious anemia
Anemia caused by vitamin B12 deficiency, which prevents normal red blood cells from being produced. Before the discovery of vitamin B12 , the disease was so severe that it was difficult to treat, and hence it was called pernicious anemia. However, it is now easily cured by administering vitamin B12 preparations. It is also called megaloblastic anemia, because of the increase in unique young red blood cell cells called megaloblasts in the bone marrow. It is common in Europe and the United States, but relatively rare in Japan. In addition to anemic and neurological symptoms, the patient suffers from Hunter glossitis, a condition in which the tongue mucosa atrophies and becomes smooth, and also lacks gastric acid. A substance called intrinsic factor in gastric juice is required for the absorption of vitamin B12 in food, but in pernicious anemia, gastric acid and intrinsic factor are not secreted due to the atrophy of the gastric mucosa. Pernicious anemia can also occur after total gastrectomy.

Source: Encyclopaedia Britannica Concise Encyclopedia About Encyclopaedia Britannica Concise Encyclopedia Information

Japanese:
ビタミン B12 の欠乏により,正常な赤血球がつくられなくなって起る貧血。ビタミン B12 が発見されるまでは,経過がきわめて悪性で治療困難であったところから,悪性貧血と名づけられたが,現在ではビタミン B12 製剤などを与えると簡単に治癒する。骨髄中に巨赤芽球という特異な若い赤血球系細胞が増加するため巨赤芽球性貧血ともいわれ,欧米に多く,日本では比較的少い。貧血症状や神経症状のほかに舌粘膜が萎縮してなめらかになるハンター舌炎という状態を呈し,また胃酸を欠く。食物中のビタミン B12 が吸収されるためには胃液中の内因子と呼ばれる物質が必要であるが,悪性貧血のときは,胃粘膜萎縮のため胃酸および内因子が分泌されなくなる。悪性貧血は胃全摘手術後に起ることもある。

出典 ブリタニカ国際大百科事典 小項目事典ブリタニカ国際大百科事典 小項目事典について 情報

<<:  Malignant malaria - Acute malaria

>>:  Malignant alopecia - Alopecia maligna

hum
hum
Blog    

Recommend

Kaunryu - Kaunryu

…The blame also extended to Song Lian, who, toget...

Red spotted crab (English name: Neopetrolisthes maculatus)

Order Decapoda, Class Malacostraca, Family Ploceid...

Father Christmas

…Today, Santa Claus has been popularized as a kin...

Hudson, Rock

Born November 17, 1925 in Winnetka, Illinois [Died...

Armân (English spelling) Arman

...They speak Aromanian (a dialect of Romanian) a...

Tischbein - Tischbein (English spelling)

This German family of painters produced more than ...

Zayd b. 'Alī (English spelling) ZaydbAli

…A Shiite sect of Islam, named after Zayd b.'...

Lobengula (English spelling)

Around 1836-94 The last king of the Ndebele Kingdo...

Allopurinol - aropurinol (English spelling)

It is a drug used to treat hyperuricemia, gout, a...

Sievert, RM (English spelling) SievertRM

…Adopted as a unit of the International System of...

Hanawa basin - Hanawabonchi

A graben basin in the upper reaches of the Yonesh...

Fox Tadanobu - Kitsuneta Danob

A character in the Joruri play "Yoshitsune Se...

Jingyoryo - Jingyoryo

This refers to the section of the Ritsuryo Code th...

Blue Sky

A coterie magazine. It was published between Janu...

Nguyen Van Thieu (English)

1923‐2001 South Vietnamese soldier and politician....