…When the body comes into contact with a pathogenic antigen (through inhalation, oral ingestion, injection, etc.), the body begins to produce antibodies against it. Among these antibodies, the immunoglobulin Ig E antibody (also called reagin) has tissue adhesion properties and adheres to the surface of mast cells present in connective tissue. When the pathogenic antigen invades again, an antigen-antibody reaction occurs on the surface of the mast cells, resulting in the degranulation of the granules contained in the mast cells, releasing chemical messengers such as histamine, SRS-A (slow reactive substance of anaphylaxis), and ECF (eosinophile chemotactic factor) from the cells. … From [Allergens]…Allergies [Masaharu Muranaka]. . . From [Bronchial Asthma] ...Aspirin asthma, in which attacks occur when taking antipyretics and analgesics, is seen in about 10% of bronchial asthma patients, but since attacks often progress rapidly to severe attacks, great care must be taken when taking medication. From [Parasite Allergy]…Richard Benedict Goldschmidt (1910) was the first to recognize allergic symptoms caused by parasites, and wrote that some zoologists studying roundworms had conjunctivitis, headaches, swelling and pain in the fingers, severe coughing attacks, and asthma symptoms. The reasons why allergic reactions occur due to parasitic infection include the fact that the parasite's body or secretions contain antigenic substances that act as allergens, and that infection easily induces helper T cells that effectively and persistently promote the production of IgE antibodies. When IgE antibodies against parasites are produced, they bind to receptors on the cell membrane of mast cells (fat cells) in tissues and basophils in the blood. … *Some of the terminology that mentions "IgE antibody" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…病因となる抗原に生体が触れると(吸入,経口,注射などの経路で),生体はそれに対して抗体を産生するようになる。これらの抗体のうち,免疫グロブリンであるIg E抗体(レアギンreaginともいう)は組織固着性があり,結合組織中に存在するマスト細胞の表面に固着する。そこに病因となる抗原が再び侵入してくると抗原抗体反応がマスト細胞の表面で起こり,その結果,マスト細胞に含まれている顆粒が脱顆粒現象を起こし,顆粒の中に含まれているヒスタミン,SRS‐A(slow reactive substance of anaphylaxis),ECF(eosinophile chemotactic factor)などの化学伝達物質を細胞外に遊離する。… 【アレルゲン】より…アレルギー【村中 正治】。。… 【気管支喘息】より…なかでも解熱鎮痛剤の服用により発作が出現するアスピリン喘息は,気管支喘息患者の約10%に見られるが,急速に重篤発作をきたす場合が多いため,薬の服用には十分な注意が必要である。 【寄生虫アレルギー】より…寄生虫によるアレルギー症状をはじめて認めたのはゴルトシュミットRichard Benedict Goldschmidt(1910)で,ウマカイチュウの研究をしている動物学者の中に結膜炎,頭痛,手指の腫張や痛み,激しい咳発作や喘息(ぜんそく)症状を示す者があることを記載している。寄生虫感染によってアレルギー反応が起こる理由としては,寄生虫の虫体あるいは分泌排出物中にアレルゲンとなる抗原物質が含まれていること,感染によってIgE抗体の産生を効果的かつ持続的に促すヘルパーT細胞が容易に誘導されてくることなどが挙げられる。寄生虫に対するIgE抗体が産生されると,それは組織内のマスト細胞(肥満細胞)や血液中の好塩基球の細胞膜上のレセプターに結合する。… ※「IgE 抗体」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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